Developmental disorders of the human brain can cause epilepsy, intellectual disability and/or autism. We study the genetics and molecular biology of the developing cerebral cortex, the brain's largest structure, to advance the understanding, diagnosis and management of human neurological disease.
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Our research achievements are peer-reviewed and published in collaboration with other scientists and clinicians around the world.

APP gene copy number changes reflect exogenous contamination

Homozygous deletions implicate non-coding epigenetic marks in Autism spectrum disorder
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Our research is currently highlighted in various media such as The Atlantic and The Wall Street Journal. Check out what our current and former lab members are up to here!

Xuyu Qian, current postdoctoral fellow in Walsh Lab was awarded the 2020 Brain Diseases Prize from UZH Foundation!
The brain diseases fund are used by the UZH Foundation for annual recognition prizes for young scientists. Every year 10,00 to 20,000 francs are awarded for particularly remarkable reasearch achievements during the doctoral studies in the field of brain diseases. Congrats Xuyu! June 2020

Congratulations to Michael Miller and his Walsh and Lee lab co-authors! Their paper "Increased Somatic Mutations in Alzheimer's Disease Neurons Illuminate Cascade of Events in Cellular Pathogenesis" has received the Terry Award for the Best Paper on Neurodegenerative Diseases. June 2020

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How did the human brain evolve? What genetic changes have made it so unique? Tackling these questions with our colleagues at the Allen Discovery Center will shed light on human nature and disease.

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