Christopher A. Walsh Laboratory
Division of Genetics & Genomics
Developmental Disorders of the Brain
We study the genetics and molecular biology of the developing cerebral cortex, the brain’s largest structure, to advance understanding, diagnosis and management of human neurological diseases, including epilepsy, intellectual disability and autism. We are applying four interrelated perspectives in our approach: Evolution, Neurological Disorders, Cell Lineage and Aging, and Functional Analysis and Modeling.
ATP1A3 Ion Pump Gene and Polymicrogyria
Richard Smith, PhD et al describe ATP1A3 mutations in individuals with polymicrogyria (PMG) and the ion pump’s role in the developing brain. Their work expands the knowledge of ATP1A3-related diseases and offers new insights into the molecular pathology of PMG and PMG-associated developmental channelopathies.
